OUR PROJECTS

Our research are of an interdisciplinary character and combine basic science with clinical sciences. The main scope of our research is based on the cardiovascular system, in particular its clinical anatomy and morphological changes of heart in various disease units. The conducted research, besides an unquestionable cognitive aspect, also provides a high potential for practical clinical use. More broadly, the topics of HEART scientific research include:

- anatomy,
- histology,
- molecular biology,
- radiology,
- cardiology,
- electrophysiology,
- cardiosurgery, 
- 3D medical imaging and 3D print. 

In particular, our scientific interests include:

- learning the exact architecture of the cardiovascular system, with particular reference to the clinical anatomy of areas of human heart that are relevant from the point of view of invasive cardiology and electrocardiology (cardioanatomy),

- myocardial imaging with the use of echocardiography and tomography as well as determining the suitability of these techniques for visualization of the anatomical details of the heart,

- identification of cell populations that build heart valves (aortic valve, pulmonary valve, and mitral valve),

- mapping (macroscopic, microscopic and molecular) of the electrical conduction system of the heart and identification of microvascularization patterns within its individual elements,

- learning the impact of pulmonary hypertension on the morphology of the right and left ventricles, and, in particular, the molecular mechanisms responsible for the left ventricle mass loss in end-stage pulmonary hypertension,

- the use of micro-computed tomography enhanced with inorganic contrasts and specific antibodies labeled with gold nanoparticles for the purpose of imaging the internal structure of the heart.

      OUR GRANTS
 

- LIDER X, National Centre for Research and Development (NCBiR), Poland (LIDER/7/0027/L-10/18/NCBR/2019)
„Virtual, interactive visualisation of the three-dimensional architecture of the human heart"
Principal investigator: Mateusz K. Hołda, Amount: 1 500 000 PLN
Implementation period: 01.03.2020-28.02.2023

- Prof. Walczak Programme, Polish National Agency for Academic Exchange, PPN/WAL/2019/1/00001/U/00001
„The use of multidetector computed tomography angiography to assess the atherosclerotic plaque volume and morphology”
Principal investigator: Mateusz K. Hołda, Amount: 58 000 PLN
Implementation period: 11.11.2019-11.03.2020

- MINIATURE 1, National Science Center of Poland, K/MNT/000012, UMO-2017/01/X/NZ4/00690
„Functional heart anatomy - new morphological and imaging research methods of the heart muscle”
Principal investigator: Mateusz K. Hołda
Amount: 40 694 PLN, Implementation period: 01.10.2017-30.09.2018

- PRELUDIUM 12, National Science Center of Poland, K/PBM/000490, UMO-2016/23/N/NZ5/00597
„Autophagy and ubiquitin-proteasome system as potential mechanisms responsible for left ventricle mass loss in a monocrotaline pulmonary hypertension rat model”
Principal investigator: Mateusz K. Hołda, Amount: 150 000 PLN
Implementation period: 1.09.2017-1.09.2020

- ESF Operational Program “Knowledge - Education - Development” under the project “Best of the best! 2.0”, MNISW/2017/98/DIR/NN2
„Morphometry of human: aortic, pulmonary, and atrioventricular valves. Anatomical basis for surgical and minimally invasive techniques for repairing heart valve defects"
Team beneficiaries: Mateusz K. Hołda, Kamil Tyrak, Jakub Hołda, Amount: 200 000 PLN
Implementation period: 20.09.2017 - 10.09.2018

- Diamond Grant 2016, Ministry of Science and Higher Education Republic of Poland K/PMI/000290, 0111/DIA/2016/45
„Changes in apoptotic gene expression and the protein profile of heart ventricles in a monocrotaline rat model of pulmonary hypertension”
Principal investigator: Mateusz K. Hołda, Amount: 220 000 PLN
Implementation period: 08.02.2017-07.12.2019

 - ESF Operational Program “Knowledge - Education - Development” under the project “Best of the best!”, MNISW/2016/DIR/182/NN
„Septal pouch - a new player on the scene of ischemic stroke"
Single beneficiary: Mateusz K. Hołda, Amount: 100 000 PLN
Implementation period: 1.03.2016-15.02.2017

- PRELUDIUM 15, National Science Center of Poland, UMO-2018/29/N/NZ5/00643
„Quantitative and qualitative protein profiling of the human sinoatrial and atrioventricular node with the use of shotgun proteomics techniques”
Principal investigator: Agata Krawczyk-Ożóg, Amount: 210 000 PLN
Implementation period: 06.03.2019-05.03.2022

- ESF Operational Program “Knowledge - Education - Development” under the project “Best of the best! 3.0”, MNiSW/2019/92/DIR/NN3
„Myocardial morphology in terms of modern imaging techniques and procedures of invasive cardiology and electrocardiology”
Team beneficiaries: Kamil Tyrak, Jakub Hołda, Amount: 120 000 PLN
Implementation period: 20.09.2018-30.05.2019

- ESF Operational Program “Knowledge - Education - Development” under the project “Best of the best! 4.0”, MNiSW/2020/218/DIR/NN4
„Human cardiovascular system - morphometry, visualization and 3D printing based on vital imaging techniques”
Team beneficiaries: Kamil Tyrak, Jakub Hołda, Amount: 100 000 PLN
Implementation period: 01.08.2019 - 30.06.2020

- ESF Operational Program “Knowledge - Education - Development” under the project “Best of the best! 4.0”, MNiSW/2020/216/DIR/NN4
„Tissue characteristics and cell populations within human heart valves”
Team beneficiaries: Maciej Lis, Bernard Solewski, Amount: 50 000 PLN
Implementation period: 01.08.2019 - 30.06.2020

- Diamond Grant 2019, Ministry of Science and Higher Education Republic of Poland, DI2018 013448
„Identification of cell populations within individual variants of the human interatrial septum, with particular emphasis on the atrial septal pouch”
Principal investigator: Kamil Tyrak, Amount: 220 000 PLN
Implementation period: 01.12.2019 - 30.11.2022

- Diamond Grant 2019, Ministry of Science and Higher Education Republic of Poland, DI2018 013348
„Architecture of microvasculature in sinoatrial and atrioventricular nodes”
Principal investigator: Jakub Hołda, Amount: 220 000 PLN
Implementation period: 01.12.2019 - 30.11.2023

- Diamond Grant 2020, Ministry of Science and Higher Education Republic of Poland, DI2019 012049
„Multimodal analysis of the microstructure of human aortic valves at the subsequent stages of their calcium degeneration”
Principal investigator: Maciej Lis, Amount: 220 000 PLN
Implementation period: 01.01.2021 - 31.12.2023              

- MINIATURE 4, National Science Center of Poland, 2020/04/X/NZ5/00050
„Analysis of variations in the course of the vessels which are significant in planning selected reconstructive surgery operations”
Principal investigator: Mateusz Koziej
Amount: 50 000 PLN, Implementation period: 01.10.2020-01.10.2021